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q-bio.MN2017
High-throughput validation of ceRNA regulatory networks
Hua-Sheng Chiu, María Rodríguez Martínez, Mukesh Bansal +5
Background: MicroRNAs (miRNAs) play multiple roles in tumor biology [1]. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive s…
q-bio.MN2006
Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
Leor S. Weinberger, John C. Burnett, Jared E. Toettcher +2
Stochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, Weinberger et al. (2005) take…