3.1k citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- Janelia Research CampusUS53 papers
- Rockefeller UniversityUS28 papers
- Harvard UniversityUS27 papers
- University of California, BerkeleyUS26 papers
- Princeton UniversityUS20 papers
- Northwestern UniversityUS17 papers
- California Institute of TechnologyUS16 papers
- Massachusetts Institute of TechnologyUS16 papers
- Stanford UniversityUS14 papers
- New York UniversityUS13 papers
- University of ChicagoUS13 papers
- Centre National de la Recherche ScientifiqueFR12 papers
23 papers · 1 filter
FILM: Mapping organellar metabolism by mid-infrared photothermal modulated fluorescence
Jianpeng Ao, Jiaze Yin, Haonan Lin +10
Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal tra…
Gene regulatory interactions limit the gene expression diversity
Orr Levy, Shubham Tripathi, Scott D. Pope +2
The diversity of expressed genes plays a critical role in cellular specialization, adaptation to environmental changes, and overall cell functionality. This diversity varies dramat…
A Markovian dynamics for C. elegans behavior across scales
Antonio C. Costa, Tosif Ahamed, David Jordan +1
How do we capture the breadth of behavior in animal movement, from rapid body twitches to aging? Using high-resolution videos of the nematode worm , we show that a sing…
Kinetics of the xanthophyll cycle and its role in photoprotective memory and response
Audrey Short, Thomas P. Fay, Thien Crisanto +4
Efficiently balancing photochemistry and photoprotection is crucial for survival and productivity of photosynthetic organisms in the rapidly fluctuating light levels found in natur…
Non-uniform growth and surface friction determine bacterial biofilm morphology on soft substrates
Chenyi Fei, Sheng Mao, Jing Yan +5
During development, organisms acquire three-dimensional shapes with important physiological consequences. While the basic mechanisms underlying morphogenesis are known in eukaryote…
Full-Field Interferometric Imaging of Propagating Action Potentials
Tong Ling, Kevin C. Boyle, Georges Goetz +5
Currently, cellular action potentials are detected using either electrical recordings or exogenous fluorescent probes sensing calcium concentration or transmembrane voltage. Ca ima…
The 2015 super-resolution microscopy roadmap
Stefan Hell, Steffen Sahl, Mark Bates +24
Far-field optical microscopy using focused light is an important tool in a number of scientific disciplines including chemical, (bio)physical and biomedical research, particularly…
Quantitative Connection Between Ensemble Thermodynamics and Single-Molecule Kinetics: A Case Study Using Cryogenic Electron Microscopy and Single-Molecule Fluorescence Resonance Energy Transfer Investigations of the Ribosome
Colin D. Kinz-Thompson, Ajeet K. Sharma, Joachim Frank +2
At equilibrium, thermodynamic and kinetic information can be extracted from biomolecular energy landscapes by many techniques. However, while static, ensemble techniques yield ther…
Controlling uncertainty in aptamer selection
Fabian Spill, Zohar B. Weinstein, Atena Irani Shemirani +3
The search for high-affinity aptamers for targets such as proteins, small molecules, or cancer cells remains a formidable endeavor. Systematic Evolution of Ligands by EXponential E…
An Unsupervised Method for Quantifying the Behavior of Interacting Individuals
Ugne Klibaite, Gordon J. Berman, Jessica Cande +2
Social behaviors involving the interaction of multiple individuals are complex and frequently crucial for an animal's survival. These interactions, ranging across sensory modalitie…
Identification of Bifurcations from Observations of Noisy Biological Oscillators
Joshua D. Salvi, Dáibhid Ó Maoiléidigh, A. J. Hudspeth
Hair bundles are biological oscillators that actively transduce mechanical stimuli into electrical signals in the auditory, vestibular, and lateral-line systems of vertebrates. A b…
Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters
Elizabeth J. Akin, Laura Solé, Ben Johnson +4
Voltage-gated sodium (Na) channels are responsible for the depolarizing phase of the action potential in most nerve cells, and Na channel localization to…
A Computational Model of YAP/TAZ Mechanosensing
Meng Sun, Fabian Spill, Muhammad H. Zaman
In cell proliferation, stem cell differentiation, chemoresistance and tissue organization, the ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numer…
Effects of 3D Geometries on Cellular Gradient Sensing and Polarization
Fabian Spill, Vivi Andasari, Michael Mak +2
During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-tempo…
Scaling and optimal synergy: Two principles determining microbial growth in complex media
Francesco Alessandro Massucci, Roger Guimerà, Luís A. Nunes Amaral +1
High-throughput experimental techniques and bioinformatics tools make it possible to obtain reconstructions of the metabolism of microbial species. Combined with mathematical frame…
Single-molecule derivation of salt dependent base-pair free energies in DNA
J. M. Huguet, C. V. Bizarro, N. Forns +3
Accurate knowledge of the thermodynamic properties of nucleic acids is crucial to predicting their structure and stability. To date most measurements of base-pair free energies in…
Force unfolding kinetics of RNA using optical tweezers. II. Modeling experiments
M. Manosas, J. -D. Wen, P. T. X. Li +4
By exerting mechanical force it is possible to unfold/refold RNA molecules one at a time. In a small range of forces, an RNA molecule can hop between the folded and the unfolded st…
Force unfolding kinetics of RNA using optical tweezers. I. Effects of experimental variables on measured results
J. -D. Wen, M. Manosas, P. T. X. Li +4
Experimental variables of optical tweezers instrumentation that affect RNA folding/unfolding kinetics were investigated. A model RNA hairpin, P5ab, was attached to two micron-sized…
A two-state kinetic model for the unfolding of single molecules by mechanical force
F. Ritort, C. Bustamante, I. Tinoco
We investigate the work dissipated during the irreversible unfolding of single molecules by mechanical force, using the simplest model necessary to represent experimental data. The…
Mechanisms of noise-resistance in genetic oscillators
Jose M. G. Vilar, Hao Yuan Kueh, Naama Barkai +1
A wide range of organisms use circadian clocks to keep internal sense of daily time and regulate their behavior accordingly. Most of these clocks use intracellular genetic networks…
Synchronisation, binding and the role of correlated firing in fast information transmission
Simon R. Schultz, Huw D. R. Golledge, Stefano Panzeri
Does synchronization between action potentials from different neurons in the visual system play a substantial role in solving the binding problem? The binding problem can be studie…
Temporal correlations and neural spike train entropy
Simon R. Schultz, Stefano Panzeri
Sampling considerations limit the experimental conditions under which information theoretic analyses of neurophysiological data yield reliable results. We develop a procedure for c…
A unified approach to the study of temporal, correlational and rate coding
S. Panzeri, S. R. Schultz
We demonstrate that the information contained in the spike occurrence times of a population of neurons can be broken up into a series of terms, each of which reflect something abou…