191 citations · 674 across the 7 of their papers we have counts for
6 papers
Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation
Jorge Escribano, Michelle B. Chen, Emad Moeendarbary +5
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infe…
Mechanical and Systems Biology of Cancer
Fabian Spill, Chris Bakal, Michael Mak
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival. The dy…
Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression
R J Seager, Cynthia Hajal, Fabian Spill +2
In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to…
Controlling uncertainty in aptamer selection
Fabian Spill, Zohar B. Weinstein, Atena Irani Shemirani +3
The search for high-affinity aptamers for targets such as proteins, small molecules, or cancer cells remains a formidable endeavor. Systematic Evolution of Ligands by EXponential E…
A Computational Model of YAP/TAZ Mechanosensing
Meng Sun, Fabian Spill, Muhammad H. Zaman
In cell proliferation, stem cell differentiation, chemoresistance and tissue organization, the ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numer…
Effects of 3D Geometries on Cellular Gradient Sensing and Polarization
Fabian Spill, Vivi Andasari, Michael Mak +2
During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-tempo…