4 papers
KINDLE: Knowledge-Guided Distillation for Prior-Free Gene Regulatory Network Inference
Rui Peng, Yuchen Lu, Qichen Sun +4
Gene regulatory network (GRN) inference serves as a cornerstone for deciphering cellular decision-making processes. Early approaches rely exclusively on gene expression data, thus…
TRIDENT: A Trimodal Cascade Generative Framework for Drug and RNA-Conditioned Cellular Morphology Synthesis
Rui Peng, Ziru Liu, Lingyuan Ye +3
Accurately modeling the relationship between perturbations, transcriptional responses, and phenotypic changes is essential for building an AI Virtual Cell (AIVC). However, existing…
MetaBench: A Multi-task Benchmark for Assessing LLMs in Metabolomics
Yuxing Lu, Xukai Zhao, J. Ben Tamo +6
Large Language Models (LLMs) have demonstrated remarkable capabilities on general text; however, their proficiency in specialized scientific domains that require deep, interconnect…
Any-to-Any Learning in Computational Pathology via Triplet Multimodal Pretraining
Qichen Sun, Zhengrui Guo, Rui Peng +2
Recent advances in computational pathology and artificial intelligence have significantly enhanced the utilization of gigapixel whole-slide images and and additional modalities (e.…