193 citations · 845 across the 19 of their papers we have counts for
3 papers · 1 filter
Direct observation and rational design of nucleation behavior in addressable self-assembly
Martin Sajfutdinow, William M. Jacobs, Aleks Reinhardt +2
In order to optimize a self-assembly reaction, it is essential to understand the factors that govern its pathway. Here, we examine the influence of nucleation pathways in a model s…
Phase transitions in biological systems with many components
William M. Jacobs, Daan Frenkel
Biological mixtures such as the cytosol may consist of thousands of distinct components. There is now a substantial body of evidence showing that, under physiological conditions, i…
Evidence of evolutionary selection for co-translational folding
William M Jacobs, Eugene I Shakhnovich
Recent experiments and simulations have demonstrated that proteins can fold on the ribosome. However, the extent and generality of fitness effects resulting from co-translational f…