17 citations · 41 across the 9 of their papers we have counts for
9 papers
Co-condensation and multivalency enable acetylation-sensitive, concentration-robust assembly of BRD4 condensates
Yury Polyachenko, Hans-Frederick Watanabe, Alexei Korolev +1
Biomolecular condensates must assemble at specific locations and times inside living cells to perform their biological functions. However, it remains unclear whether condensate for…
A thermodynamic metric quantitatively predicts disordered protein partitioning and multicomponent phase behavior
Zhuang Liu, Beijia Yuan, Mihir Rao +2
Intrinsically disordered regions (IDRs) of proteins mediate sequence-specific interactions underlying diverse cellular processes, including the formation of biomolecular condensate…
When is Not Enough: Evaluating Simple Metrics for Predicting Phase Separation of Intrinsically Disordered Proteins
Wesley W. Oliver, William M. Jacobs, Michael A. Webb
Understanding and predicting the phase behavior of intrinsically disordered proteins (IDPs) is of significant interest due to their role in many biological processes. However, effe…
Cooperation and competition of basepairing and electrostatic interactions in mixtures of DNA nanostars and polylysine
Gabrielle R. Abraham, Tianhao Li, Anna Nguyen +2
Phase separation in biomolecular mixtures can result from multiple physical interactions, which may act either complementarily or antagonistically. In the case of protein-nucleic a…
Dynamical phase transition in the growth of programmable polymorphic materials
Fan Chen, William M. Jacobs
The hallmark feature of polymorphic systems is their ability to assemble into many possible structures at the same thermodynamic state. Designer polymorphic materials can in princi…
Predicting Heteropolymer Phase Separation Using Two-Chain Contact Maps
Jessica Jin, Wesley Oliver, Michael A. Webb +1
Phase separation in polymer solutions often correlates with single-chain and two-chain properties, such as the single-chain radius of gyration, Rg, and the pairwise second virial c…
Predicting the morphology of multiphase biomolecular condensates from protein interaction networks
Tianhao Li, William M. Jacobs
Phase-separated biomolecular condensates containing proteins and RNAs can assemble into higher-order structures by forming thermodynamically stable interfaces between immiscible ph…
Emergence of multiphase condensates from a limited set of chemical building blocks
Fan Chen, William M. Jacobs
Biomolecules composed of a limited set of chemical building blocks can co-localize into distinct, spatially segregated compartments known as biomolecular condensates. While many co…
Competition between self-assembly and phase separation governs high-temperature condensation of a DNA liquid
Omkar Hegde, Tianhao Li, Anjali Sharma +3
In many biopolymer solutions, attractive interactions that stabilize finite-sized clusters at low concentrations also promote phase separation at high concentrations. Here we study…