193 citations · 845 across the 19 of their papers we have counts for
3 papers · 1 filter
Oligomers of heat-shock proteins: Structures that don't imply function
William M. Jacobs, Tuomas P. J. Knowles, Daan Frenkel
Most proteins must remain soluble in the cytosol in order to perform their biological functions. To protect against undesired protein aggregation, living cells maintain a populatio…
Rational design of self-assembly pathways for complex multicomponent structures
William M. Jacobs, Aleks Reinhardt, Daan Frenkel
The field of complex self-assembly is moving toward the design of multi-particle structures consisting of thousands of distinct building blocks. To exploit the potential benefits o…
Theoretical prediction of free-energy landscapes for complex self-assembly
William M. Jacobs, Aleks Reinhardt, Daan Frenkel
We present a technique for calculating free-energy profiles for the nucleation of multicomponent structures that contain as many species as building blocks. We find that a key fact…