79 citations · 79 across the 2 of their papers we have counts for
4 papers
Understanding the role of phenotypic switching in cancer drug resistance
Einar Bjarki Gunnarsson, Subhajyoti De, Kevin Leder +1
The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, rece…
Mutation timing in a spatial model of evolution
Jasmine Foo, Kevin Leder, Jason Schweinsberg
Motivated by models of cancer formation in which cells need to acquire mutations to become cancerous, we consider a spatial population model in which the population is represen…
Splitting Algorithms for Rare Events of Semimartingale Reflecting Brownian motions
Kevin Leder, Xin Liu, Zicheng Wang
We study rare event simulations of semimartingale reflecting Brownian motions (SRBMs) in an orthant. The rare event of interest is that a -dimensional positive recurrent SRBM en…
Robust and probabilistic optimization of dose schedules in radiotherapy
Hamidreza Badri, Yoichi Watanabe, Kevin Leder
We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if in…