79 citations · 237 across the 20 of their papers we have counts for
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Large Deviations of Cancer Recurrence Timing
Pranav Hanagal, Kevin Leder, Zicheng Wang
We study large deviation events in the timing of disease recurrence. In particular, we are interested in modeling cancer treatment failure due to mutation-induced drug resistance.…
Spread of premalignant mutant clones and cancer initiation in multilayered tissue
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
Over 80% of human cancers originate from the epithelium, which covers the outer and inner surfaces of organs and blood vessels. In stratified epithelium, the bottom layers are occu…
Understanding the role of phenotypic switching in cancer drug resistance
Einar Bjarki Gunnarsson, Subhajyoti De, Kevin Leder +1
The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, rece…
Mutation timing in a spatial model of evolution
Jasmine Foo, Kevin Leder, Jason Schweinsberg
Motivated by models of cancer formation in which cells need to acquire mutations to become cancerous, we consider a spatial population model in which the population is represen…