79 citations · 237 across the 20 of their papers we have counts for
5 papers · 1 filter
Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data
C. Wu, E. B. Gunnarsson, E. M. Myklebust +6
Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety…
Dynamics of advantageous mutant spread in spatial death-birth and birth-death Moran models
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
The spread of an advantageous mutation through a population is of fundamental interest in population genetics. While the classical Moran model is formulated for a well-mixed popula…
Exact site frequency spectra of neutrally evolving tumors: a transition between power laws reveals a signature of cell viability
Einar Bjarki Gunnarsson, Kevin Leder, Jasmine Foo
The site frequency spectrum (SFS) is a popular summary statistic of genomic data. While the SFS of a constant-sized population undergoing neutral mutations has been extensively stu…
Understanding the role of phenotypic switching in cancer drug resistance
Einar Bjarki Gunnarsson, Subhajyoti De, Kevin Leder +1
The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, rece…
Multifocality and recurrence risk: a quantitative model of field cancerization
Jasmine Foo, Kevin Leder, Marc Ryser
Primary tumors often emerge within genetically altered fields of premalignant cells that appear histologically normal but have a high chance of progression to malignancy. Clinical…