193 citations · 761 across the 33 of their papers we have counts for
5 papers · 1 filter
Statistics of optimal information flow in ensembles of regulatory motifs
Andrea Crisanti, Andrea De Martino, Jonathan Fiorentino
Genetic regulatory circuits universally cope with different sources of noise that limit their ability to coordinate input and output signals. In many cases, optimal regulatory perf…
Constraint-based inverse modeling of metabolic networks: a proof of concept
Daniele De Martino, Andrea De Martino
We consider the problem of inferring the probability distribution of flux configurations in metabolic network models from empirical flux data. For the simple case in which experime…
Quantifying the entropic cost of cellular growth control
Daniele De Martino, Fabrizio Capuani, Andrea De Martino
We quantify the amount of regulation required to control growth in living cells by a Maximum Entropy approach to the space of underlying metabolic states described by genome-scale…
Translating ceRNA susceptibilities into correlation functions
Araks Martirosyan, Matteo Marsili, Andrea De Martino
Competition to bind microRNAs induces an effective positive crosstalk between their targets, therefore known as `competing endogenous RNAs' or ceRNAs. While such an effect is known…
Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype
Jorge Fernandez-de-Cossio-Diaz, Andrea De Martino, Roberto Mulet
We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient…