83 citations · 91 across the 8 of their papers we have counts for
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q-bio.CB2003
Complexity in the Immune System
Michael W. Deem
The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and…
cond-mat.stat-mech2003★ 83 cited
Sequence Space Localization in the Immune System Response to Vaccination and Disease
Michael W. Deem, Ha Youn Lee
We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccina…
cond-mat.stat-mech2003★ 8 cited
Two-Dimensional Diffusion in the Presence of Topological Disorder
Ligang Chen, Michael W. Deem
How topological defects affect the dynamics of particles hopping between lattice sites of a distorted, two-dimensional crystal is addressed. Perturbation theory and numerical simul…