204 citations · 763 across the 45 of their papers we have counts for
Showing 2025Show all
3 papers · 1 filter
q-bio.BM2025
The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
Jamieson A L Howard, Benjamin Ambrose, Mahmoud A S Abdelhamid +10
DNA helicases undergo conformational changes; however, their structural dynamics are poorly understood. Here, we study single molecules of superfamily 1A DNA helicase Rep, which un…
physics.bio-ph2025
Single-molecule biophysics
Mark C Leake
Biological molecules, like all active matter, use free energy to generate force and motion which drive them out of thermal equilibrium, and undergo inherent dynamic interconversion…
physics.bio-ph2025
Invention, Innovation, and Commercialisation in British Biophysics
Jack Shepherd, Mark Leake
British biophysics has a tradition of scientific invention and innovation, resulting in new technologies transforming biological insight, such as rapid DNA sequencing, super-resolu…