204 citations · 763 across the 45 of their papers we have counts for
8 papers · 1 filter
Single-molecule studies of the dynamics and interactions of bacterial OXPHOS complexes
Tchern Lenn, Mark C. Leake
Although significant insight has been gained into biochemical, genetic and structural features of oxidative phosphorylation (OXPHOS) at the single-enzyme level, relatively little w…
Innovative Science
Donald W Braben, John F Allen, William Amos +45
Sir, We write as senior scientists about a problem vital to the scientific enterprise and prosperity. Nowadays, funding is a lengthy and complex business. First, universities thems…
Millisecond single-molecule localization microscopy combined with convolution analysis and automated image segmentation to determine protein concentrations in complexly structured, functional cells, one cell at a time
Adam J. M. Wollman, Mark C. Leake
We present a single-molecule tool called the CoPro (Concentration of Proteins) method that uses millisecond imaging with convolution analysis, automated image segmentation and supe…
Developing a new biophysical tool to combine magneto-optical tweezers with super-resolution fluorescence microscopy
Zhaokun Zhou, Helen Miller, Adam J. M. Wollman +1
We present a novel experimental setup in which magnetic and optical tweezers are combined for torque and force transduction onto single filamentous molecules in a transverse config…
From Animaculum to single-molecules: 300 years of the light microscope
Adam J. M. Wollman, Richard Nudd, Erik G. Hedlund +1
Although not laying claim to being the inventor of the light microscope, Antonj van Leeuwenhoek, (1632-1723) was arguably the first person to bring this new technological wonder of…
Probing DNA interactions with proteins using a single-molecule toolbox: inside the cell, in a test tube, and in a computer
Adam J. M. Wollman, Helen Miller, Zhaokun Zhou +1
DNA-interacting proteins have roles multiple processes, many operating as molecular machines which undergo dynamic metastable transitions to bring about their biological function.…