67 citations · 142 across the 11 of their papers we have counts for
13 papers
Walsh coefficients and circuits for several alleles
Kristina Crona, Devin Greene
Walsh coefficients have been applied extensively to biallelic systems for quantifying pairwise and higher order epistasis, in particular for demonstrating the empirical importance…
Irreversible evolution, obstacles in fitness landscapes and persistent drug resistance
Kristina Crona
We use fitness graphs, or directed cube graphs, for analyzing evolutionary reversibility. The main application is antimicrobial drug resistance. Reversible drug resistance has been…
Geometry of fitness landscapes: Peaks, shapes and universal positive epistasis
Kristina Crona, Joachim Krug, Malvika Srivastava
Darwinian evolution is driven by random mutations, genetic recombination (gene shuffling) and selection that favors genotypes with high fitness. For systems where each genotype can…
Sign Epistasis and the Geometry of Interactions
Kristina Crona
Approaches to gene interactions based on sign epistasis have been highly influential in recent time. Sign epistasis is useful for relating local and global properties of fitness la…
Higher order epistasis and fitness peaks
Kristina Crona, Mengming Luo
We show that higher order epistasis has a substantial impact on evolutionary dynamics by analyzing peaks in the fitness landscapes. There are 193,270,310 fitness graphs, or cube or…
Epistasis and Entropy
Kristina Crona
Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some rec…