The Changing Geometry of a Fitness Landscape Along an Adaptive Walk

Abstract

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomemon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.

29 pages, 7 figures

References in corpus (4)

• Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes
• Epistasis and Shapes of Fitness Landscapes
• The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
• Antibiotic resistance landscapes: a quantification of theory-data incompatibility for fitness landscapes

Cited by in corpus (4)

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• Adaptation in tunably rugged fitness landscapes: The Rough Mount Fuji Model
• The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
• Getting higher on rugged landscapes: Inversion mutations open access to fitter adaptive peaks in NK fitness landscapes