5 citations · 8 across the 4 of their papers we have counts for
5 papers · 1 filter
Walsh coefficients and circuits for several alleles
Kristina Crona, Devin Greene
Walsh coefficients have been applied extensively to biallelic systems for quantifying pairwise and higher order epistasis, in particular for demonstrating the empirical importance…
Irreversible evolution, obstacles in fitness landscapes and persistent drug resistance
Kristina Crona
We use fitness graphs, or directed cube graphs, for analyzing evolutionary reversibility. The main application is antimicrobial drug resistance. Reversible drug resistance has been…
Sign Epistasis and the Geometry of Interactions
Kristina Crona
Approaches to gene interactions based on sign epistasis have been highly influential in recent time. Sign epistasis is useful for relating local and global properties of fitness la…
Epistasis and Entropy
Kristina Crona
Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large system where systematic fitness measurements may not be possible. Some rec…
Antibiotic resistance landscapes: a quantification of theory-data incompatibility for fitness landscapes
Kristina Crona, Dayonna Patterson, Kelly Stack +6
Fitness landscapes are central in analyzing evolution, in particular for drug resistance mutations for bacteria and virus. We show that the fitness landscapes associated with antib…