67 citations · 142 across the 11 of their papers we have counts for
4 papers · 1 filter
The Changing Geometry of a Fitness Landscape Along an Adaptive Walk
Devin Greene, Kristina Crona
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in N…
Evolutionary Predictability and Complications with Additivity
Kristina Crona, Devin Greene, Miriam Barlow
Adaptation is a central topic in theoretical biology, of practical importance for analyzing drug resistance mutations. Several authors have used arguments based on extreme value th…
Antibiotic resistance landscapes: a quantification of theory-data incompatibility for fitness landscapes
Kristina Crona, Dayonna Patterson, Kelly Stack +6
Fitness landscapes are central in analyzing evolution, in particular for drug resistance mutations for bacteria and virus. We show that the fitness landscapes associated with antib…
Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes
Christiane P. Goulart, Mentar Mahmudi, Kristina A. Crona +5
The evolution of antibiotic resistance among bacteria threatens our continued ability to treat infectious diseases. The need for sustainable strategies to cure bacterial infections…