165 citations · 1.3k across the 51 of their papers we have counts for
22 papers · 1 filter
Detection of signaling mechanisms from cellular responses to multiple cues
Soutick Saha, Hye-ran Moon, Bumsoo Han +1
Cell signaling networks are complex and often incompletely characterized, making it difficult to obtain a comprehensive picture of the mechanisms they encode. Mathematical modeling…
Temporal precision of regulated gene expression
Shivam Gupta, Julien Varennes, Hendrik C. Korswagen +1
Important cellular processes such as migration, differentiation, and development often rely on precise timing. Yet, the molecular machinery that regulates timing is inherently nois…
Role of spatial averaging in multicellular gradient sensing
Tyler Smith, Sean Fancher, Andre Levchenko +2
Gradient sensing underlies important biological processes including morphogenesis, polarization, and cell migration. The precision of gradient sensing increases with the length of…
Optimal Prediction by Cellular Signaling Networks
Nils B. Becker, Andrew Mugler, Pieter Rein ten Wolde
Living cells can enhance their fitness by anticipating environmental change. We study how accurately linear signaling networks in cells can predict future signals. We find that max…
Molecular clustering digitizes signaling and increases fidelity
Edward Roob, Nicola Trendel, Pieter Rein ten Wolde +1
Many membrane-bound molecules in cells form small clusters. It has been hypothesized that these clusters convert an analog extracellular signal into a digital intracellular signal…
Stochastic modeling of gene expression, protein modification, and polymerization
Andrew Mugler, Sean Fancher
Many fundamental cellular processes involve small numbers of molecules. When numbers are small, fluctuations dominate, and stochastic models, which account for these fluctuations,…