62 citations · 126 across the 4 of their papers we have counts for
4 papers
Lethal Mutagenesis in Viruses and Bacteria
Peiqiu Chen, Eugene I. Shakhnovich
Here we study how mutations which change physical properties of cell proteins (stability) impact population survival and growth. In our model the genotype is presented as a set of…
The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
Konstantin Zeldovich, Peiqiu Chen, Eugene Shakhnovich
Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study popula…
A first-principles model of early evolution: Emergence of gene families, species and preferred protein folds
Konstantin Zeldovich, Peiqiu Chen, Boris Shakhnovich +1
In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in…
Theory of quantum impurities in spin liquids
Alexei Kolezhuk, Subir Sachdev, Rudro R. Biswas +1
We describe spin correlations in the vicinity of a generalized impurity in a wide class of fractionalized spin liquid states. We argue that the primary characterization of the impu…