62 citations · 64 across the 3 of their papers we have counts for
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q-bio.BM2009
Lethal Mutagenesis in Viruses and Bacteria
Peiqiu Chen, Eugene I. Shakhnovich
Here we study how mutations which change physical properties of cell proteins (stability) impact population survival and growth. In our model the genotype is presented as a set of…
q-bio.BM2007★ 2 cited
The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
Konstantin Zeldovich, Peiqiu Chen, Eugene Shakhnovich
Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study popula…