2 papers
q-bio.BM2009
Thermal Adaptation in Viruses and Bacteria
Peiqiu Chen, Eugene I. Shakhnovich
A previously established multiscale population genetics model states that fitness can be inferred from the physical properties of proteins under the physiological assumption that a…
q-bio.BM2009
Lethal Mutagenesis in Viruses and Bacteria
Peiqiu Chen, Eugene I. Shakhnovich
Here we study how mutations which change physical properties of cell proteins (stability) impact population survival and growth. In our model the genotype is presented as a set of…