62 citations · 126 across the 4 of their papers we have counts for
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q-bio.BM2007★ 2 cited
The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
Konstantin Zeldovich, Peiqiu Chen, Eugene Shakhnovich
Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study popula…
q-bio.BM2007★ 62 cited
A first-principles model of early evolution: Emergence of gene families, species and preferred protein folds
Konstantin Zeldovich, Peiqiu Chen, Boris Shakhnovich +1
In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in…