6 citations · 9 across the 7 of their papers we have counts for
7 papers
Adaptive therapy under parametric, structural, and measurement uncertainty
Alexander P Browning, Rebecca M Crossley, Ryan J Murphy +2
Adaptive therapy has emerged as a promising treatment strategy that exploits within-tumour competition to delay disease progression. Implementation, however, typically relies on in…
Parameter Identifiability Under Limited Experimental Data in Age-Structured Models of the Cell Cycle
Ruby E. Nixson, Helen M. Byrne, Joe M. Pitt-Francis +1
The mitotic cell cycle governs DNA replication and cell division. The effectiveness of radiotherapy and chemotherapy depends on cell-cycle position, with increased resistance durin…
Stochastic modelling reveals that chromatin folding buffers epigenetic landscapes against sirtuin depletion during DNA damage
Daria Stepanova, Helen M. Byrne, Tomás Alarcón
Epigenetic landscapes, represented by patterns of chemical modifications on histone tails, are essential for maintaining cell identity and tissue homeostasis. These landscapes are…
Understanding how chromatin folding and enzyme competition affect rugged epigenetic landscapes
Daria Stepanova, Meritxell Brunet Guasch, Helen M. Byrne +1
Epigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigene…
Using a probabilistic approach to derive a two-phase model of flow-induced cell migration
Yaron Ben-Ami, Joe M. Pitt-Francis, Philip K. Maini +1
Interstitial fluid flow is a feature of many solid tumours. In vitro Experiments have shown that such fluid flow can direct tumour cell movement upstream or downstream depending on…
The role of mechanics in the growth and homeostasis of the intestinal crypt
Axel A. Almet, Helen M. Byrne, Philip K. Maini +1
We present a mechanical model of tissue homeostasis that is specialised to the intestinal crypt. Growth and deformation of the crypt, idealised as a line of cells on a substrate, a…
Optimisation of Simulations of Stochastic Processes by Removal of Opposing Reactions
Fabian Spill, Philip K. Maini, Helen Byrne
Models invoking the chemical master equation are used in many areas of science, and, hence, their simulation is of interest to many researchers. The complexity of the problems at h…