6 papers
Topological Inference for Organoids
Haochen Yang, Byung Ho Lee, Anne Grapin-Botton +2
The reproducibility of organ morphology and the extent to which computational models can predict morphogenesis remain difficult to quantify, particularly for organs with complex ne…
Topology of Multi-species Localization
Abhinav Natarajan, Thomas Chaplin, Joshua A. Bull +5
Spatial relationships in multi-species data can indicate and affect system outcomes and behaviors, ranging from disease progression in cancer to coral reef resilience in ecology; t…
Topological shape transform for thymus structures
Haochen Yang, Vadim Lebovici, Andreas Tarcevski +5
The Euler characteristic transform (ECT) is an emerging and powerful framework within topological data analysis for quantifying the geometry of shape. The applicability of ECT has…
TopROI: A topology-informed network approach for tissue partitioning
Sergio Serrano de Haro Iváñez, Joshua W. Moore, Lucile Grzesiak +4
Mammalian tissue architecture is central to biological function, and its disruption is a hallmark of disease. Medical imaging techniques can generate large point cloud datasets tha…
Topology across Scales on Heterogeneous Cell Data
Maria Torras-Pérez, Iris H. R. Yoon, Praveen Weeratunga +4
Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. I…
Topological model selection: a case-study in tumour-induced angiogenesis
Robert A McDonald, Helen M Byrne, Heather A Harrington +2
Comparing mathematical models offers a means to evaluate competing scientific theories. However, exact methods of model calibration are not applicable to many probabilistic models…