activity
20102022
most citedProtein folding and binding can emerge as evolutionary spandrels through structural coupling

77 citations · 298 across the 18 of their papers we have counts for

collaborators

19 papers

eess.IV2022★ 11 cited

Gradient-Based Geometry Learning for Fan-Beam CT Reconstruction

Mareike Thies, Fabian Wagner, Noah Maul +10

Incorporating computed tomography (CT) reconstruction operators into differentiable pipelines has proven beneficial in many applications. Such approaches usually focus on the proje…

eess.IV2020★ 9 cited

Appearance Learning for Image-based Motion Estimation in Tomography

Alexander Preuhs, Michael Manhart, Philipp Roser +5

In tomographic imaging, anatomical structures are reconstructed by applying a pseudo-inverse forward model to acquired signals. Geometric information within this process is usually…

eess.IV2020★ 3 cited

Data Consistent CT Reconstruction from Insufficient Data with Learned Prior Images

Yixing Huang, Alexander Preuhs, Michael Manhart +2

Image reconstruction from insufficient data is common in computed tomography (CT), e.g., image reconstruction from truncated data, limited-angle data and sparse-view data. Deep lea…

cs.LG2019

Deep autofocus with cone-beam CT consistency constraint

Alexander Preuhs, Michael Manhart, Philipp Roser +5

High quality reconstruction with interventional C-arm cone-beam computed tomography (CBCT) requires exact geometry information. If the geometry information is corrupted, e. g., by…

eess.IV2019★ 1 cited

Image Quality Assessment for Rigid Motion Compensation

Alexander Preuhs, Michael Manhart, Philipp Roser +5

Diagnostic stroke imaging with C-arm cone-beam computed tomography (CBCT) enables reduction of time-to-therapy for endovascular procedures. However, the prolonged acquisition time…

eess.IV2019★ 6 cited

Data Consistent Artifact Reduction for Limited Angle Tomography with Deep Learning Prior

Yixing Huang, Alexander Preuhs, Guenter Lauritsch +3

Robustness of deep learning methods for limited angle tomography is challenged by two major factors: a) due to insufficient training data the network may not generalize well to uns…

physics.med-ph2018

Maximum Likelihood Estimation of Head Motion using Epipolar Consistency

Alexander Preuhs, Nishant Ravikumar, Michael Manhart +5

Open gantry C-arm systems that are placed within the interventional room enable 3-D imaging and guidance for stroke therapy without patient transfer. This can profit in drastically…

physics.med-ph2018★ 3 cited

Fast Epipolar Consistency without the Need for Pseudo Matrix Inverses

Alexander Preuhs, Michael Manhart, Andreas Maier

Interventional C-arm systems allow flexible 2-D imaging of a 3-D scene while being capable of cone beam computed tomography. Due to the flexible structure of the C-arm, the rotatio…

math.NA2018★ 4 cited

Numerical simulation of transport in porous media: some problems from micro to macro scale

Quanji Cai, Sheema Kooshapur, Michael Manhart +4

This paper deals with simulation of flow and transport in porous media such as transport of groundwater contaminants. We first discuss how macro scale equations are derived and whi…

physics.med-ph2018★ 11 cited

Double Your Views - Exploiting Symmetry in Transmission Imaging

Alexander Preuhs, Andreas Maier, Michael Manhart +3

For a plane symmetric object we can find two views - mirrored at the plane of symmetry - that will yield the exact same image of that object. In consequence, having one image of a…

q-bio.PE2018★ 54 cited

Growth tradeoffs produce complex microbial communities on a single limiting resource

Michael Manhart, Eugene I. Shakhnovich

The relationship between the dynamics of a community and its constituent pairwise interactions is a fundamental problem in ecology. Higher-order ecological effects beyond pairwise…

cs.CE2015★ 9 cited

Pore-scale lattice Boltzmann simulation of laminar and turbulent flow through a sphere pack

Ehsan Fattahia, Christian Waluga, Barbara Wohlmuth +3

The lattice Boltzmann method can be used to simulate flow through porous media with full geometrical resolution. With such a direct numerical simulation, it becomes possible to stu…

cond-mat.stat-mech2015★ 13 cited

Path statistics, memory, and coarse-graining of continuous-time random walks on networks

Michael Manhart, Willow Kion-Crosby, Alexandre V. Morozov

Continuous-time random walks (CTRWs) on discrete state spaces, ranging from regular lattices to complex networks, are ubiquitous across physics, chemistry, and biology. Models with…

q-bio.PE2014★ 4 cited

Scaling properties of evolutionary paths in a biophysical model of protein adaptation

Michael Manhart, Alexandre V. Morozov

The enormous size and complexity of genotypic sequence space frequently requires consideration of coarse-grained sequences in empirical models. We develop scaling relations to quan…

q-bio.PE2014★ 77 cited

Protein folding and binding can emerge as evolutionary spandrels through structural coupling

Michael Manhart, Alexandre V. Morozov

Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interaction…

q-bio.PE2013★ 50 cited

Biophysical Fitness Landscapes for Transcription Factor Binding Sites

Allan Haldane, Michael Manhart, Alexandre V. Morozov

Evolutionary trajectories and phenotypic states available to cell populations are ultimately dictated by intermolecular interactions between DNA, RNA, proteins, and other molecular…

q-bio.PE2013★ 13 cited

Statistical Physics of Evolutionary Trajectories on Fitness Landscapes

Michael Manhart, Alexandre V. Morozov

Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landsc…

q-bio.PE2013★ 19 cited

A path-based approach to random walks on networks characterizes how proteins evolve new function

Michael Manhart, Alexandre V. Morozov

We develop a path-based approach to continuous-time random walks on networks with arbitrarily weighted edges. We describe an efficient numerical algorithm for calculating statistic…

physics.flu-dyn2010★ 11 cited

A priori and a posteriori analysis of models for Large-Eddy simulation of particle-laden flow

Ch. Gobert, M. Manhart

In Large-Eddy simulation of particle-laden flow, the effect of the unresolved scales on the particles needs to be modelled. In this work we analyse three very promising models, nam…