77 citations · 298 across the 18 of their papers we have counts for
6 papers · 1 filter
Growth tradeoffs produce complex microbial communities on a single limiting resource
Michael Manhart, Eugene I. Shakhnovich
The relationship between the dynamics of a community and its constituent pairwise interactions is a fundamental problem in ecology. Higher-order ecological effects beyond pairwise…
Scaling properties of evolutionary paths in a biophysical model of protein adaptation
Michael Manhart, Alexandre V. Morozov
The enormous size and complexity of genotypic sequence space frequently requires consideration of coarse-grained sequences in empirical models. We develop scaling relations to quan…
Protein folding and binding can emerge as evolutionary spandrels through structural coupling
Michael Manhart, Alexandre V. Morozov
Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interaction…
Biophysical Fitness Landscapes for Transcription Factor Binding Sites
Allan Haldane, Michael Manhart, Alexandre V. Morozov
Evolutionary trajectories and phenotypic states available to cell populations are ultimately dictated by intermolecular interactions between DNA, RNA, proteins, and other molecular…
Statistical Physics of Evolutionary Trajectories on Fitness Landscapes
Michael Manhart, Alexandre V. Morozov
Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landsc…
A path-based approach to random walks on networks characterizes how proteins evolve new function
Michael Manhart, Alexandre V. Morozov
We develop a path-based approach to continuous-time random walks on networks with arbitrarily weighted edges. We describe an efficient numerical algorithm for calculating statistic…