77 citations · 298 across the 18 of their papers we have counts for
3 papers · 1 filter
Biophysical Fitness Landscapes for Transcription Factor Binding Sites
Allan Haldane, Michael Manhart, Alexandre V. Morozov
Evolutionary trajectories and phenotypic states available to cell populations are ultimately dictated by intermolecular interactions between DNA, RNA, proteins, and other molecular…
Statistical Physics of Evolutionary Trajectories on Fitness Landscapes
Michael Manhart, Alexandre V. Morozov
Random walks on multidimensional nonlinear landscapes are of interest in many areas of science and engineering. In particular, properties of adaptive trajectories on fitness landsc…
A path-based approach to random walks on networks characterizes how proteins evolve new function
Michael Manhart, Alexandre V. Morozov
We develop a path-based approach to continuous-time random walks on networks with arbitrarily weighted edges. We describe an efficient numerical algorithm for calculating statistic…