77 citations · 298 across the 18 of their papers we have counts for
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q-bio.PE2014★ 4 cited
Scaling properties of evolutionary paths in a biophysical model of protein adaptation
Michael Manhart, Alexandre V. Morozov
The enormous size and complexity of genotypic sequence space frequently requires consideration of coarse-grained sequences in empirical models. We develop scaling relations to quan…
q-bio.PE2014★ 77 cited
Protein folding and binding can emerge as evolutionary spandrels through structural coupling
Michael Manhart, Alexandre V. Morozov
Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interaction…