3 papers
q-bio.PE2020
About the Protein Space Vastness
Jorge A. Vila
An accurate estimation of the Protein Space size, in light of the factors that govern it, is a long-standing problem and of paramount importance in evolutionary biology, since it d…
q-bio.BM2020
Metamorphic Proteins in light of the Anfinsen Dogma
Jorge A. Vila
It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins n…
q-bio.BM2018
Guessing the upper bound free-energy difference between native-like structures
Jorge A. Vila
Use of a combination of statistical thermodynamics and the Gershgorin theorem enable us to guess, in the thermodynamic limit, a plausible value for the upper bound free-energy diff…