14 citations · 15 across the 5 of their papers we have counts for
7 papers
Rethinking the protein folding problem from a new perspective
Jorge A. Vila
One of the main concerns of Anfinsen was to reveal the connection between the amino acid sequence and their biologically active conformation. This search gave rise to two crucial q…
Protein Folding: From Classical Issues to a New Perspective
Jorge A. Vila
The Levinthal paradox exposes many critical questions on the protein folding problem, among which we could point out why proteins can reach their native state in a biologically rea…
Proteins Evolution Upon Point Mutations
J. A. Vila
The primary aim of this work is to explore how proteins point mutations impact their marginal stability and, hence, their evolvability. With this purpose, we show that the use of f…
Thoughts on the Proteins Native State
Jorge A. Vila
The presence of metamorphism in the protein's native state is not yet fully understood. In an attempt to throw light on this issue here we present an assessment, in terms of the am…
About the Protein Space Vastness
Jorge A. Vila
An accurate estimation of the Protein Space size, in light of the factors that govern it, is a long-standing problem and of paramount importance in evolutionary biology, since it d…
Metamorphic Proteins in light of the Anfinsen Dogma
Jorge A. Vila
It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins n…