14 citations · 15 across the 5 of their papers we have counts for
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Rethinking the protein folding problem from a new perspective
Jorge A. Vila
One of the main concerns of Anfinsen was to reveal the connection between the amino acid sequence and their biologically active conformation. This search gave rise to two crucial q…
Protein Folding: From Classical Issues to a New Perspective
Jorge A. Vila
The Levinthal paradox exposes many critical questions on the protein folding problem, among which we could point out why proteins can reach their native state in a biologically rea…
Thoughts on the Proteins Native State
Jorge A. Vila
The presence of metamorphism in the protein's native state is not yet fully understood. In an attempt to throw light on this issue here we present an assessment, in terms of the am…
Metamorphic Proteins in light of the Anfinsen Dogma
Jorge A. Vila
It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins n…
Guessing the upper bound free-energy difference between native-like structures
Jorge A. Vila
Use of a combination of statistical thermodynamics and the Gershgorin theorem enable us to guess, in the thermodynamic limit, a plausible value for the upper bound free-energy diff…