Guessing the upper bound free-energy difference between native-like structures
arXiv:1811.08885 · doi:10.1016/j.physa.2019.122053
Abstract
Use of a combination of statistical thermodynamics and the Gershgorin theorem enable us to guess, in the thermodynamic limit, a plausible value for the upper bound free-energy difference between native-like structures of monomeric globular proteins. Support to our result in light of both the observed free-energy change between the native and denatured states and the microstability free-energy values obtained from the observed micro-unfolding tendency of nine globular proteins, will be here discussed.