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Self-organized lane-formation in bidirectional transport of molecular motors
Robin Jose, Ludger Santen
Within cells, vesicles and proteins are actively transported several micrometers along the cytoskeletal filaments. The transport along microtubules is propelled by dynein and kines…
Cell-Type-Specific Differences in KDEL Receptor Clustering in Mammalian Cells
Achim Bauer, Ludger Santen, Manfred J. Schmitt +2
In eukaryotic cells, KDEL receptors (KDELRs) facilitate the retrieval of endoplasmic reticulum (ER) luminal proteins from the Golgi compartment back to the ER. Apart from the well-…
Trapping in and escape from branched structures of neuronal dendrites
Robin Jose, Ludger Santen, M. Reza Shaebani
We present a coarse-grained model for stochastic transport of noninteracting chemical signals inside neuronal dendrites and show how first-passage properties depend on the key stru…
Run-and-pause dynamics of cytoskeletal motor proteins
Anne E. Hafner, Ludger Santen, Heiko Rieger +1
Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. The motor exhibits distinct state…
Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
Cecile Appert-Rolland, Maximilian Ebbinghaus, Ludger Santen
Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organell…
Motility states in bidirectional cargo transport
Sarah Klein, Cecile Appert-Rolland, Ludger Santen
Intracellular cargos which are transported by molecular motors move stochastically along cytoskeleton filaments. In particular for bidirectionally transported cargos it is an open…