Environmental control of microtubule-based bidirectional cargo-transport

Abstract

Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question how the cell can control this bias. Here we develop a model which takes explicitly into account the elastic coupling of the cargo with each motor. We show that bias can be simply controlled or even reversed in a counterintuitive manner via a change in the external force exerted on the cargo or a variation of the ATP binding rate to motors. Furthermore, the superdiffusive behavior found at short time scales indicates the emergence of motor cooperation induced by cargo-mediated coupling.

References in corpus (4)

• Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
• Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
• The role of microtubule movement in bidirectional organelle transport
• Cargo transportation by two species of motor protein

Cited by in corpus (6)

• Nonequilibrium Physics in Biology
• Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
• Motility states in bidirectional cargo transport
• Fluctuation effects in bidirectional cargo transport
• A parity breaking Ising chain Hamiltonian as a Brownian motor
• Stochastic modeling of cargo transport by teams of molecular motors