Genetic Toggle Switch Without Cooperative Binding

Abstract

Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.

10 pages,4 figures

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• Molecular Distributions in Gene Regulatory Dynamics
• Reaction coordinates for the flipping of genetic switches
• Functions of Bifans in Context of Multiple Regulatory Motifs in Signaling Networks
• Unfair and Anomalous Evolutionary Dynamics from Fluctuating Payoffs
• A stochastic and dynamical view of pluripotency in mouse embryonic stem cells
• Genetic Toggle Switch in the Absence of Cooperative Binding: Exact Results
• Eliminating fast reactions in stochastic simulations of biochemical networks: a bistable genetic switch
• Rare-Event Sampling of Epigenetic Landscapes and Phenotype Transitions
• Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
• Efficient Stochastic Simulations of Complex Reaction Networks on Surfaces
• Model reduction methods for classical stochastic systems with fast-switching environments: reduced master equations, stochastic differential equations, and applications
• Fluctuations in Gene Regulatory Networks as Gaussian Colored Noise
• Quantitative Analysis of a Transient Dynamics of a Gene Regulatory Network
• Complete integrability of information processing by biochemical reactions
• Statistical physics of a model binary genetic switch with linear feedback
• Mean-field vs. stochastic models for transcriptional regulation
• Analytic solutions for stochastic hybrid models of gene regulatory networks
• An "All Possible Steps" Approach to the Accelerated Use of Gillespie's Algorithm
• Analytical study of an exclusive genetic switch
• Approximation scheme based on effective interactions for stochastic gene regulation
• Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and post-transcriptional regulations
• Lambda-prophage induction modeled as a cooperative failure mode of lytic repression
• Stationary distributions of continuous-time Markov chains: a review of theory and truncation-based approximations
• Evaluation of the Multiplane Method for Efficient Simulations of Reaction Networks
• Markov State Models of Gene Regulatory Networks
• The origin of the Poisson distribution in stochastic dynamics of gene expression
• Deterministic and Stochastic Simulations of Simple Genetic Circuits
• Reconstructing an epigenetic landscape using a genetic `pulling' approach