Genetic Toggle Switch Without Cooperative Binding

Abstract

Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.

10 pages,4 figures

References in corpus (2)

• Molecular Discreteness in Reaction-Diffusion Systems Yields Steady States Not Seen in the Continuum Limit
• Modeling of negative autoregulated genetic networks in single cells

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• Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
• Efficient Stochastic Simulations of Complex Reaction Networks on Surfaces
• Statistical physics of a model binary genetic switch with linear feedback
• Mean-field vs. stochastic models for transcriptional regulation
• An "All Possible Steps" Approach to the Accelerated Use of Gillespie's Algorithm
• Evaluation of the Multiplane Method for Efficient Simulations of Reaction Networks
• Deterministic and Stochastic Simulations of Simple Genetic Circuits