Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

Abstract

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.

References in corpus (6)

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• Oscillations and temporal signalling in cells
• A core genetic module : the Mixed Feedback Loop
• Stochastic Simulations of the Repressilator Circuit
• Reaction coordinates for the flipping of genetic switches

Cited by in corpus (7)

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• A robust two-gene oscillator at the core of Ostreococcus tauri circadian clock
• Entrainment of noise-induced and limit cycle oscillators under weak noise
• Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression
• The heterodimer auto-repression loop: a robust and flexible pulse-generating genetic module
• Stochastic oscillations induced by intrinsic fluctuations in a self-repressing gene: a deterministic approach