Dynamic-OCT simulation framework based on mathematical models of intratissue dynamics, image formation, and measurement noise

Abstract

Dynamic optical coherence tomography (DOCT) enables label-free functional imaging by capturing temporal OCT signal variations caused by intracellular and intratissue motions. However, the relationship between DOCT signals and the sample motion behind them remains unclear. This paper presents a comprehensive DOCT simulation framework that incorporates mathematical models of intracellular/intratissue motions, two OCT signal generator types that generate OCT signal time sequences from the moving scatterer models, and representative DOCT algorithms. The theory and algorithms of the framework are described in detail, and the utility of this framework is demonstrated through numerical studies. This framework is available as open source and will enhance the understanding and utility of DOCT.

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Cited by in corpus (2)

• Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers
• Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals