activity
20222026
most citedLabel-free intratissue activity imaging of alveolar organoids with dynamic optical coherence tomography

42 citations · 146 across the 25 of their papers we have counts for

collaborators

25 papers

physics.optics2026

High-speed volumetric amplitude-spectrum dynamic optical coherence tomography by neural network with multi-burst scanning

Yusong Liu, Ibrahim Abd El-Sadek, Atsuko Furukawa +3

Dynamic optical coherence tomography (DOCT) enables label-free, three-dimensional (3D) assessment of tissue dynamics. However, it suffers from long acquisition times because conven…

physics.optics2026

Numerical speckle reduction for optical coherence tomography based on an analytical image formation model

Xibo Wang, Shuichi Makita, Nobuhisa Tateno +6

Speckle is an intrinsic granular pattern that limits the effective resolution of optical coherence tomography (OCT). We propose a numerical speckle reduction method using the "real…

physics.optics2026

Image-based investigation of the zebrafish developmental process using in vivo dynamic and multi-contrast optical coherence tomography

Cunyou Bao, Shadil Basheer, Aiyi Sui +6

We demonstrate in vivo dynamic optical coherence tomography (DOCT) imaging of zebrafish development from 2 weeks to 12 months post-fertilization, integrated with polarization-sensi…

physics.optics2026

Neural-network-based high-speed and high-definition full-field dynamic optical coherence tomography

Suzuyo Komeda, Nobuhisa Tateno, Yusong Liu +7

A neural-network (NN)-based method for high-speed, high-definition dynamic optical coherence tomography (DOCT) using full-field swept-source optical coherence microscopy (FF-SS-OCM…

physics.optics2025★ 3 cited

Dynamic full-field swept-source optical coherence microscope for cellular-resolution, long-depth, and intratissue-activity imaging

Nobuhisa Tateno, Yue Zhu, Suzuyo Komeda +8

Optical coherence tomography (OCT) microscope (OCM) uses a high-numerical-aperture objective to achieve cellular-level lateral resolution. However, its practical imaging depth rang…

physics.med-ph2025★ 8 cited

Dynamic-OCT simulation framework based on mathematical models of intratissue dynamics, image formation, and measurement noise

Yuanke Feng, Shumpei Fujimura, Yiheng Lim +6

Dynamic optical coherence tomography (DOCT) enables label-free functional imaging by capturing temporal OCT signal variations caused by intracellular and intratissue motions. Howev…

physics.optics2025★ 1 cited

In vivo dynamic optical coherence tomography of human skin with hardware- and software-based motion correction

Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek +10

In vivo application of dynamic optical coherence tomography (DOCT) is hindered by bulk motion of the sample. We demonstrate DOCT imaging of \invivo human skin by adopting a sample-…

physics.optics2025★ 1 cited

Unified image formation theory for microscopy and optical coherence tomography in 4-D space-time

Naoki Fukutake, Shuichi Makita, Yoshiaki Yasuno

We construct an image formation theory that covers the majority of optical microscopy techniques that use diverse coherent or incoherent light-matter interactions. The theories of…

physics.optics2025

Four-dimensional image formation theory of optical coherence tomography

Naoki Fukutake, Shuichi Makita, Yoshiaki Yasuno

We construct an accurate imaging theory for optical coherence tomography/microscopy (OCT/OCM) without approximations to calculate precise optical resolution and imaging characteris…

physics.optics2025★ 2 cited

Image formation theory of optical coherence tomography with optical aberrations and its application for computational aberration correction

Shuichi Makita, Naoki Fukutake, Lida Zhu +1

Computational corrections of defocus and aberrations in optical coherence tomography (OCT) offers a promising approach to realize high-resolution imaging with deep imaging depth, b…

physics.optics2025★ 2 cited

Theoretical analysis of performance limitation of computational refocusing in optical coherence tomography

Yue Zhu, Shuichi Makita, Naoki Fukutake +1

High-numerical-aperture optical coherence tomography (OCT) enables sub-cellular imaging but faces a trade-off between lateral resolution and depth of focus. Computational refocusin…

physics.optics2024★ 10 cited

Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers

Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek +8

Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratiss…

physics.bio-ph2024★ 7 cited

Optical-coherence-tomography-based deep-learning scatterer-density estimator using physically accurate noise model

Thitiya Seesan, Pradipta Mukherjee, Ibrahim Abd El-Sadek +4

We demonstrate a deep-learning-based scatterer density estimator (SDE) that processes local speckle patterns of optical coherence tomography (OCT) images and estimates the scattere…

physics.optics2024★ 3 cited

Multiple scattering suppression for in vivo optical coherence tomography measurement using B-scan-wise multi-focus averaging method

Yiqiang Zhu, Lida Zhu, Yiheng Lim +3

We demonstrate a method that reduces the noise caused by multi-scattering (MS) photons in an \invivo optical coherence tomography image. This method combines a specially designed i…

physics.med-ph2024★ 8 cited

Neural-network based high-speed volumetric dynamic optical coherence tomography

Yusong Liu, Ibrahim Abd El-Sadek, Rion Morishita +5

Wedemonstratedeep-learningneuralnetwork(NN)-baseddynamicopticalcoherence tomography (DOCT), which generates high-quality logarithmic-intensity-variance (LIV) DOCT images from only…

physics.optics2023★ 8 cited

Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus averaging

Lida Zhu, Shuichi Makita, Junya Tamaoki +4

Polarization-sensitive optical coherence tomography (PS-OCT) is a promising biomedical imaging tool for differentiation of various tissue properties. However, the presence of multi…

physics.optics2023★ 10 cited

Multi-focus averaging for multiple scattering suppression in optical coherence tomography

Lida Zhu, Shuichi Makita, Junya Tamaoki +4

Multiple scattering is one of the main factors that limits the penetration depth of optical coherence tomography (OCT) in scattering samples. We propose a method termed multi-focus…

physics.optics2023★ 19 cited

Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging

Kiriko Tomita, Shuichi Makita, Naoki Fukutake +10

A new formulation of lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are pres…

physics.bio-ph2023★ 42 cited

Label-free intratissue activity imaging of alveolar organoids with dynamic optical coherence tomography

Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek +8

An organoid is a three-dimensional (3D) in vitro cell culture emulating human organs. We applied 3D dynamic optical coherence tomography (DOCT) to visualize the intratissue and int…

physics.med-ph2022★ 1 cited

Optical coherence tomography -- principles, implementation, and applications in ophthalmology

Yoshiaki Yasuno

This short textbook was written for someone who newly start studying, doing research, or development about optical coherence tomography (OCT) or using OCT. The first chapter summar…

physics.med-ph2022★ 2 cited

Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography

Ibrahim Abd El-Sadek, Larina Tzu-Wei Shen, Tomoko Mori +5

We demonstrate label-free drug response evaluations of human breast (MCF-7) and colon (HT-29) cancer spheroids via dynamic optical coherence tomography (OCT). The MCF-7 and HT-29 s…

physics.med-ph2022★ 11 cited

Multi-contrast Jones-matrix optical coherence tomography -- the concept, principle, implementation, and applications

Yoshiaki Yasuno

Jones-matrix optical coherence tomography (JM-OCT) is an extension of OCT that provides multiple types of optical contrasts of biological and clinical samples. JM-OCT measures the…

physics.med-ph2022★ 6 cited

Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network

Shuichi Makita, Masahiro Miura, Shinnosuke Azuma +2

Degree of polarization uniformity (DOPU) imaging obtained by polarization-sensitive optical coherence tomography (PS-OCT) has the potential to provide biomarkers for retinal diseas…

physics.med-ph2022

Critique of optical coherence tomography in epistemological metrology

Yoshiaki Yasuno

This treaties aims to introduce a speculative framework to comprehend modern metrology. In a classical sense, measurement measures physically existing quantities, such as length, m…