Optical Widefield Nuclear Magnetic Resonance Microscopy
arXiv:2402.18239 · doi:10.1038/s41467-024-55003-5
Abstract
Microscopy enables detailed visualization and understanding of minute structures or processes. While cameras have significantly advanced optical, infrared, and electron microscopy, imaging nuclear magnetic resonance (NMR) signals on a camera has remained elusive. Here, we employ nitrogen-vacancy (NV) centers in diamond as a quantum sensor, which converts NMR signals into optical signals that are subsequently captured by a high-speed camera. Unlike traditional magnetic resonance imaging (MRI), our method records the NMR signal over a wide field of view in real space. We demonstrate that our optical widefield NMR microscopy (OMRM) can image NMR signals in microfluidic structures with a resolution across a area. Crucially, each camera pixel records an NMR spectrum providing multicomponent information about the signal's amplitude, phase, local magnetic field strengths, and gradients. The fusion of optical microscopy and NMR techniques enables multifaceted imaging applications in the physical and life sciences.
References in corpus (16)
- Quantum sensing
- Universal dynamical decoupling of a single solid-state spin from a spin bath
- High Resolution Magnetic Resonance Spectroscopy Using Solid-State Spins
- Sub-millihertz magnetic spectroscopy with a nanoscale quantum sensor
- Quantum sensing with arbitrary frequency resolution
- Nanoscale NMR Spectroscopy and Imaging of Multiple Nuclear Species
- Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor
- Quantum diamond spectrometer for nanoscale NMR and ESR spectroscopy
- One- and two-dimensional nuclear magnetic resonance spectroscopy with a diamond quantum sensor
- NV-Diamond Magnetic Microscopy using a Double Quantum 4-Ramsey Protocol
- Practical Concepts for Design, Construction and Application of Halbach Magnets in Magnetic Resonance
- Simultaneous Wide-field Imaging of Phase and Magnitude of AC Magnetic Signal Using Diamond Quantum Magnetometry
- High speed microcircuit and synthetic biosignal widefield imaging using nitrogen vacancies in diamond
- Geometry dependence of micron-scale NMR signals on NV-diamond chips
- High homogeneity permanent magnet for diamond magnetometry
- Wide-field diamond magnetometry with millihertz frequency resolution and nanotesla sensitivity