Stochastic thermodynamics of chemical reactions coupled to finite reservoirs: A case study for the Brusselator

Abstract

Biomolecular processes are typically modeled using chemical reaction networks coupled to infinitely large chemical reservoirs. A difference in chemical potential between these reservoirs can drive the system into a non-equilibrium steady state (NESS). In reality, these processes take place in finite systems containing a finite number of molecules. In such systems, a NESS can be reached with the help of an externally driven pump for which we introduce a simple model. Crucial parameters are the pumping rate and the finite size of the chemical reservoir. We apply this model to a simple biochemical oscillator, the Brusselator, and quantify the performance using the number of coherent oscillations. As a surprising result, we find that higher precision can be achieved with finite-size reservoirs even though the corresponding current fluctuations are larger than in the ideal infinite case.

arXiv comment8 pages, 5 figures

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• Dissipation at limited resolutions: Power law and detection of hidden dissipative scales
• Deficiency, Kinetic Invertibility, and Catalysis in Stochastic Chemical Reaction Networks
• Irreversibility in Non-reciprocal Chaotic Systems
• What is a chemostat? Insights from hybrid dynamics and stochastic thermodynamics