Thermodynamics of Concentration vs Flux Control in Chemical Reaction Networks

Abstract

We investigate the thermodynamic implications of two control mechanisms of open chemical reaction networks. The first controls the concentrations of the species that are exchanged with the surroundings, while the other controls the exchange fluxes. We show that the two mechanisms can be mapped one into the other and that the thermodynamic theories usually developed in the framework of concentration control can be applied to flux control as well. This implies that the thermodynamic potential and the fundamental forces driving chemical reaction networks out of equilibrium can be identified in the same way for both mechanisms. By analyzing the dynamics and thermodynamics of a simple enzymatic model we also show that, while the two mechanisms are equivalent at steady state, the flux control may lead to fundamentally different regimes where systems achieve stationary growth.

References in corpus (9)

• Ensemble and Trajectory Thermodynamics: A Brief Introduction
• Stochastic thermodynamics of chemical reaction networks
• Irreversible thermodynamics of open chemical networks I: Emergent cycles and broken conservation laws
• Thermodynamic uncertainty relation and thermodynamic speed limit in deterministic chemical reaction networks
• Emergence of homochirality in large molecular systems
• Nonequilibrium Thermodynamics of Non-Ideal Chemical Reaction Networks
• Negative differential response in chemical reactions
• Length and sequence relaxation of copolymers under recombination reactions
• A robust transition to homochirality in complex chemical reaction networks

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• Dissipation in Hydrodynamics from Micro- to Macroscale: Wisdom from Boltzmann and Stochastic Thermodynamics
• Random walks on modular chains: Detecting structure through statistics
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• What is a chemostat? Insights from hybrid dynamics and stochastic thermodynamics
• Free-Energy Transduction in Chemical Reaction Networks: from Enzymes to Metabolism
• Coarse Graining Photo-Isomerization Reactions: Thermodynamic Consistency and Implications for Molecular Ratchets
• Information Thermodynamics for Deterministic Chemical Reaction Networks