Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces
arXiv:1904.00448 · doi:10.1088/1361-6633/ab37ca
Abstract
At the heart of the structured architecture and complex dynamics of biological systems are specific and timely interactions operated by biomolecules. In many instances, biomolecular agents are spatially confined to flexible lipid membranes where, among other functions, they control cell adhesion, motility and tissue formation. Besides being central to several biological processes, \emph{multivalent interactions} mediated by reactive linkers confined to deformable substrates underpin the design of synthetic-biological platforms and advanced biomimetic materials. Here we review recent advances on the experimental study and theoretical modelling of a heterogeneous class of biomimetic systems in which synthetic linkers mediate multivalent interactions between fluid and deformable colloidal units, including lipid vesicles and emulsion droplets. Linkers are often prepared from synthetic DNA nanostructures, enabling full programmability of the thermodynamic and kinetic properties of their mutual interactions. The coupling of the statistical effects of multivalent interactions with substrate fluidity and deformability gives rise to a rich emerging phenomenology that, in the context of self-assembled soft materials, has been shown to produce exotic phase behaviour, stimuli-responsiveness, and kinetic programmability of the self-assembly process. Applications to (synthetic) biology will also be reviewed.
arXiv comment63 pages, review
References in corpus (34)
- Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles
- Multistep kinetic self-assembly of DNA-coated colloids
- Mechanisms of pattern formation during T cell adhesion
- A general theory of DNA-mediated and other valence-limited interactions
- Volume and porosity thermal regulation in lipid mesophases by coupling mobile ligands to soft membranes
- Specificity, flexibility and valence of DNA bonds guide emulsion architecture
- Biomimetic emulsions reveal the effect of homeostatic pressure on cell-cell adhesion
- Colloidomers: freely-jointed polymers made of droplets
- Mobile linkers on DNA-coated colloids: valency without patches
- Binding constants of membrane-anchored receptors and ligands: a general theory corroborated by Monte Carlo simulations
- Theory and Simulation of DNA-Coated Colloids: a Guide for Rational Design
- A simple analytical formula for the free-energy of ligand-receptor mediated interactions
- An Effective Membrane Model of the Immunological Synapse
- Quantitative prediction of the phase diagram of DNA-functionalized nano-colloids
- Kinetic limitations of cooperativity based drug delivery systems
- Controlling the temperature sensitivity of DNA-mediated colloidal interactions through competing linkages
- Colloidal supported lipid bilayers for self-assembly
- The Role of Optical Projection in the Analysis of Membrane Fluctuations
- Microparticle assembly pathways on lipid membranes
- Adhesion-induced phase separation of multiple species of membrane junctions
- Flexibility defines structure in crystals of amphiphilic DNA nanostars
- Exploiting Receptors Competition to Enhance Nanoparticles Binding Selectivity
- Controlling cargo trafficking in multicomponent membranes
- Bond formation kinetics affects self-assembly directed by ligand-receptor interactions
- Entropy stabilizes floppy crystals of mobile DNA-coated colloids
- Free energy of ligand-receptor systems forming multimeric complexes
- Simple approach for calculating the binding free energy of a multivalent particle
- Modeling the relative dynamics of DNA-coated colloids
- A new configurational bias scheme for sampling supramolecular structures
- Steric interactions between mobile ligands facilitate complete wrapping in passive endocytosis
- Oil-in-water microfluidics on the colloidal scale: new routes to self-assembly and glassy packings
- Surface-triggered cascade reactions between DNA linkers direct self-assembly of colloidal crystals of controllable thickness
- Switch-like surface binding of competing multivalent particles
- Multivalent "Attacker & Guard" Strategy for Targeting Surfaces with Low Receptor Density
Cited by in corpus (4)
- Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
- Direct visualization of superselective colloid-surface binding mediated by multivalent interactions
- A Coarse-Grained Simulation Model for Self-Assembly of Liquid Droplets Featuring Explicit Mobile Binders
- Sliding across a surface: particles with fixed and mobile ligands