Free energy of ligand-receptor systems forming multimeric complexes

Abstract

Ligand-receptor interactions are ubiquitous in biology and have become popular in materials in view of their applications to programmable self-assembly. Although, complex functionalities often emerge from the simultaneous interaction of more than just two linker molecules, state of art theoretical frameworks enable the calculation of the free energy only in systems featuring one-to-one ligand/receptor binding. In this communication we derive a general formula to calculate the free energy of a system featuring simultaneous direct interaction between an arbitrary number of linkers. To exemplify the potential and generality of our approach we apply it to the systems recently introduced by Parolini et al. [ACS Nano 10, 2392 (2016)] and Halverson et al. [J. Chem. Phys. 144, 094903 (2016)], both featuring functioanlized Brownian particles interacting via three-linker complexes.

arXiv comment5 pages with 3 figures in the main text. 8 pages with 2 figures in the supporting information. Second version with updated bibliography and fixed typos. Accepted for publication J. Chem. Phys. (Communication)

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Cited by in corpus (7)

• Programmable interactions with biomimetic DNA linkers at fluid membranes and interfaces
• Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
• Bond formation kinetics affects self-assembly directed by ligand-receptor interactions
• Linker-mediated phase behavior of DNA-coated colloids
• First-Order "Hyper-selective" Binding Transition of Multivalent Particles Under Force
• Multivalent "Attacker & Guard" Strategy for Targeting Surfaces with Low Receptor Density
• Designed self-assembly of programmable colloidal atom-electron equivalents