Hyperpolarization-enhanced NMR spectroscopy with femtomole sensitivity using quantum defects in diamond
arXiv:1810.02408 · doi:10.1103/PhysRevX.10.021053
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a widely used tool for chemical analysis and molecular structure identification. Because it typically relies on the weak magnetic fields produced by a small thermal nuclear spin polarization, NMR suffers from poor molecule-number sensitivity compared to other analytical techniques. Recently, a new class of NMR sensors based on optically-probed nitrogen-vacancy (NV) quantum defects in diamond have allowed molecular spectroscopy from sample volumes several orders of magnitude smaller than the most sensitive inductive detectors. To date, however, NV-NMR spectrometers have only been able to observe signals from pure, highly concentrated samples. To overcome this limitation, we introduce a technique that combines picoliter-scale NV-NMR with fully integrated Overhauser dynamic nuclear polarization (DNP) to perform high-resolution spectroscopy on a variety of small molecules in dilute solution, with femtomole sensitivity. Our technique advances mass-limited NMR spectroscopy for drug and natural product discovery, catalysis research, and single cell studies.
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Cited by in corpus (25)
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- Surface NMR using quantum sensors in diamond
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- High-Resolution NMR Spectroscopy at Large Fields with Nitrogen Vacancy Centers
- Roadmap on Nanoscale Magnetic Resonance Imaging
- Geometry dependence of micron-scale NMR signals on NV-diamond chips
- Correlated noise in Brownian motion allows for super resolution
- Ferrimagnetic Oscillator Magnetometer
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