Statistical Mechanics Model for the Dynamics of Collective Epigenetic Histone Modification

Abstract

Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.

Published in PRL

References in corpus (1)

• Epigenetic Chromatin Silencing: Bistability and Front Propagation

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