320 citations · 482 across the 7 of their papers we have counts for
7 papers
Investigating Epithelial-To-Mesenchymal Transition with Integrated Computational and Experimental Approaches
Jianhua Xing, Xiao-Jun Tian
The transition between epithelial and mesenchymal (EMT) is a fundamental cellular process that plays critical roles in development, cancer metastasis, and tissue wound healing. EMT…
Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis
Xiao-Jun Tian, Dong Zhou, Haiyan Fu +5
Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents e…
mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision
Xiao-Jun Tian, Hang Zhang, Jingyu Zhang +1
miRNAs serve as crucial post-transcriptional regulators in various essential cell fate decision. However, the contribution of the mRNA-miRNA mutual regulation to bistability is not…
Achieving Diverse and Monoallelic Olfactory Receptor Selection Through Dual-Objective Optimization Design
Xiao-Jun Tian, Hang Zhang, Jens Sannerud +1
Multiple-objective optimization is common in biological systems. In the mammalian olfactory system, each sensory neuron stochastically expresses only one out of up to thousands of…
Computational modeling to elucidate molecular mechanisms of epigenetic memory
Jianhua Xing, Jin Yu, Hang Zhang +1
How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin sta…
Statistical Mechanics Model for the Dynamics of Collective Epigenetic Histone Modification
Hang Zhang, Xiao-Jun Tian, Abhishek Mukhopadhyay +2
Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns…
Coupled Reversible and Irreversible Bistable Switches Underlying TGF-β-induced Epithelial to Mesenchymal Transition
Xiao-Jun Tian, Hang Zhang, Jianhua Xing
Epithelial to mesenchymal transition (EMT) plays important roles in embryonic development, tissue regeneration and cancer metastasis. While several feedback loops have been shown t…