Translocation of stiff polymers through a nanopore driven by binding particles

Abstract

We investigate the translocation of stiff polymers in the presence of binding particles through a nanopore by two-dimensional Langevin dynamics simulations. We find that the mean translocation time shows a minimum as a function of the binding energy $\epsilon$ and the particle concentration $\varphi$, due to the interplay of the force from binding and the frictional force. Particularly, for the strong binding the translocation proceeds with a decreasing translocation velocity induced by a significant increase of the frictional force. In addition, both $\epsilon$ and $\varphi$ have an notable impact on the distribution of the translocation time. With increasing $\epsilon$ and $\varphi$, it undergoes a transition from an asymmetric and broad distribution under the weak binding to a nearly Gaussian one under the strong binding, and its width becomes gradually narrower.

7 pages, 6 figures, accepted to J. Chem. Phys

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Cited by in corpus (1)

• Chaperone-assisted translocation of flexible polymers in three dimensions