Single Stranded DNA Translocation Through A Nanopore: A Master Equation Approach

Abstract

We study voltage driven translocation of a single stranded (ss) DNA through a membrane channel. Our model, based on a master equation (ME) approach, investigates the probability density function (pdf) of the translocation times, and shows that it can be either double or mono-peaked, depending on the system parameters. We show that the most probable translocation time is proportional to the polymer length, and inversely proportional to the first or second power of the voltage, depending on the initial conditions. The model recovers experimental observations on hetro-polymers when using their properties inside the pore, such as stiffness and polymer-pore interaction.

7 pages submitted to PRE

References in corpus (2)

• Polymer Translocation througha Pore in a Membrane
• Driven Polymer Translocation Through a Narrow Pore

Cited by in corpus (12)

• Dynamics of Molecular Motors and Polymer Translocation with Sequence Heterogeneity
• Forced translocation of a polymer: dynamical scaling vs. MD-simulation
• Translocation of structured polynucleotides through nanopores
• Chaperone assisted translocation
• Enhancement of charged macromolecule capture by nanopores in a salt gradient
• Directed motion emerging from two coupled random processes: Translocation of a chain through a membrane nanopore driven by binding proteins
• Non-driven polymer translocation through a nanopore: computational evidence that the escape and relaxation processes are coupled
• Some New Aspects of Dendrimer Applications
• Effect of Inhomogeneity in Translocation of Polymers through Nanopores
• Translocation of a Single Stranded DNA Through a Conformationally Changing Nanopore
• Translocation of polymers with folded configurations across nanopores
• Translocation of stiff polymers through a nanopore driven by binding particles