Measuring protein concentration with entangled photons
arXiv:1109.3128 · doi:10.1063/1.4724105
Abstract
Optical interferometry is amongst the most sensitive techniques for precision measurement. By increasing the light intensity a more precise measurement can usually be made. However, in some applications the sample is light sensitive. By using entangled states of light the same precision can be achieved with less exposure of the sample. This concept has been demonstrated in measurements of fixed, known optical components. Here we use two-photon entangled states to measure the concentration of the blood protein bovine serum albumin (BSA) in an aqueous buffer solution. We use an opto-fluidic device that couples a waveguide interferometer with a microfluidic channel. These results point the way to practical applications of quantum metrology to light sensitive samples.
References in corpus (12)
- Silica-on-Silicon Waveguide Quantum Circuits
- Beating the Standard Quantum Limit with Four Entangled Photons
- Entanglement-free Heisenberg-limited phase estimation
- Optimal Quantum Phase Estimation
- Manipulating multi-photon entanglement in waveguide quantum circuits
- A Quantum-Enhanced Prototype Gravitational-Wave Detector
- Polarization entangled state measurement on a chip
- Quantum metrology with imperfect states and detectors
- Generation of Large Number-Path Entanglement Using Linear Optics and Feed-Forward
- Loss-Induced Limits to Phase Measurement Precision with Maximally Entangled States
- Beating the standard quantum limit: Phase super-sensitivity of N-photon interferometers
- High-fidelity operation of quantum photonic circuits
Cited by in corpus (75)
- Biological measurement beyond the quantum limit
- Anderson localization of entangled photons in an integrated quantum walk
- An Entanglement-Enhanced Microscope
- Spontaneous parametric down-conversion
- Quantum optical technologies for metrology, sensing and imaging
- Realisation of the first sub shot noise wide field microscope
- Quantum photonics at telecom wavelengths based on lithium niobate waveguides
- Quantum Photonic Interconnect
- Phase sensing beyond the standard quantum limit with a truncated SU(1,1) interferometer
- Quantum Plasmonic Sensors
- A tradeoff in simultaneous quantum-limited phase and loss estimation in interferometry
- Photon number correlation for quantum enhanced imaging and sensing
- Linear Optical Quantum Metrology with Single Photons: Exploiting Spontaneously Generated Entanglement to Beat the Shot-Noise Limit
- Femtosecond laser micromachining for integrated quantum photonics
- Tutorial: Optical quantum metrology
- Quantum interferometry with three-dimensional geometry
- Quantum imaging with sub-Poissonian light: challenges and perspectives in optical metrology
- Readout of superconducting nanowire single-photon detectors at high count rates
- Practical Quantum Metrology
- Experimental multiphase estimation on a chip
- Multiboson Correlation Interferometry with arbitrary single-photon pure states
- Tuneable quantum interference in a 3D integrated circuit
- Retrieving ideal precision in noisy quantum optical metrology
- Quantum plasmonic sensing: beyond the shot-noise and diffraction limit
- Quantum-enhanced interferometry with large heralded photon-number states
- Quantum enhancement of accuracy and precision in optical interferometry
- A search algorithm for quantum state engineering and metrology
- The role of entanglement in calibrating optical quantum gyroscopes
- Quantum optical rotatory dispersion
- Quantum plasmonic N00N state in a silver nanowire and its use for quantum sensing
- Mode engineering for realistic quantum-enhanced interferometry
- Spectrally pure single photons at telecommunications wavelengths using commercial birefringent optical fiber
- Coherent characterisation of a single molecule in a photonic black box
- Tapering of fs Laser-written Waveguides
- Quantum metrology in local dissipative environments
- Multiphase estimation without a reference mode
- Optimal Gaussian Metrology for Generic Multimode Interferometric Circuit
- Experimental multiparameter quantum metrology in adaptive regime
- Adaptive Tracking of Enzymatic Reactions with Quantum Light
- Attaining sub-classical metrology in lossy systems with entangled coherent states
- Estimating phase with a random generator: Strategies and resources in multiparameter quantum metrology
- Experimental quantum polarimetry using heralded single photons
- Quantum metrology in the noisy intermediate-scale quantum era
- Critical Theory for the Breakdown of Photon Blockade
- Multipath Correlation Interference and Controlled-NOT Gate Simulation with a Thermal Source
- Quantum Process Tomography by 2D Fluorescence Spectroscopy
- Creating mid-infrared single photons
- Spatial interference between pairs of disjoint optical paths with a single chaotic source
- Quantum-enhanced metrology with the single-mode coherent states of an optical cavity inside a quantum feedback loop
- Quantum Jump Metrology
- Trends of biosensing: plasmonics through miniaturization and quantum sensing
- Manipulation of Multimode Squeezing in a Coupled Waveguide Array
- Two-photon phase-sensing with single-photon detection
- Invisibility Cloak Printed on a Photonic Chip
- High-precision Quantum Transmitometry of DNA and Methylene-Blue using a Frequency-Entangled Twin-Photon Beam in Type-I SPDC
- Hybrid waveguide-bulk multi-path interferometer with switchable amplitude and phase
- Number-unconstrained quantum sensing
- Non-Markovian effect on quantum optical metrology under dissipative environment
- Towards probing for hypercomplex quantum mechanics in a waveguide interferometer
- Probabilistic metrology or how some measurement outcomes render ultra-precise estimates
- Probing Ultra-Fast Dephasing via Entangled Photon Pairs
- Light, the universe, and everything -- 12 Herculean tasks for quantum cowboys and black diamond skiers
- Continuous-variable phase-estimation with unitary and random linear disturbance
- Quantum-enhanced atomic gyroscope with tunable precision
- Quantum plasmonics model of refractive index sensing using photon correlations
- Quantum plasmonic sensing by Hong-Ou-Mandel interferometry
- Maximising Precision in Saturation-Limited Absorption Measurements
- Quantum Simulation of Bound-State-Enhanced Quantum Metrology
- Quantum jump metrology in a two-cavity network
- Quantum metrology of a structured reservoir
- Super sensitivity and super resolution with quantum teleportation
- Joint estimation of phase and phase diffusion for quantum metrology
- Quantum-like nonlinear interferometry with frequency-engineered classical light
- Stationary two-qubit entanglement mediated by one-dimensional plasmonic nanoarrays
- Dose-efficient Quantum Phase Estimation in Lossy Optical Interferometry