28 citations
- Bayer (Germany)DE2 papers
- Boehringer Ingelheim (Germany)DE2 papers
- Bristol-Myers Squibb (United States)US2 papers
- Janssen (Germany)DE2 papers
- Merck KGaA, Darmstadt (Germany)DE2 papers
- Novartis (Switzerland)CH2 papers
- Pfizer (Germany)DE2 papers
- Roche (Switzerland)CH2 papers
- Universitätsmedizin GöttingenDE2 papers
- University of FreiburgDE2 papers
- Bristol-Myers Squibb (Sweden)SE1 paper
- Eli Lilly (Germany)DE1 paper
5 papers
Statistical Operating Characteristics of Current Early Phase Dose Finding Designs with Toxicity and Efficacy in Oncology
Hao Sun, Hsin-Yu Lin, Jieqi Tu +2
Traditional phase I dose finding cancer clinical trial designs aim to determine the maximum tolerated dose (MTD) of the investigational cytotoxic agent based on a single toxicity o…
Survival analysis for AdVerse events with VarYing follow-up times (SAVVY) -- estimation of adverse event risks
Regina Stegherr, Claudia Schmoor, Jan Beyersmann +12
The SAVVY project aims to improve the analyses of adverse event (AE) data in clinical trials through the use of survival techniques appropriately dealing with varying follow-up tim…
Survival analysis for AdVerse events with VarYing follow-up times (SAVVY) -- comparison of adverse event risks in randomized controlled trials
Kaspar Rufibach, Regina Stegherr, Claudia Schmoor +12
Analyses of adverse events (AEs) are an important aspect of the evaluation of experimental therapies. The SAVVY (Survival analysis for AdVerse events with Varying follow-up times)…
Review of Quantitative Systems Pharmacological Modeling in Thrombosis
Limei Cheng, Guo-Wei Wei, Tarek Leil
Hemostasis and thrombosis are often thought as two sides of the same clotting mechanism whereas hemostasis is a natural protective mechanism to prevent bleeding and thrombosis is a…
Statistical modeling of the time course of tantrum anger
Peihua Qiu, Rong Yang, Michael Potegal
Although anger is an important emotion that underlies much overt aggression at great social cost, little is known about how to quantify anger or to specify the relationship between…